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RyR1 Joins the Cryo-EM 'Resolution Revolution'

  • Jun 6, 2017
  • 1 min read

RyR1 Clusters of mutation hot spots are now identified in recent Cryo-EM structures (reviewed here). Disease-causing ryanodine receptor 1 (RyR1) mutations (http://www.uniprot.org/uniprot/P21817) in the N-terminal domain (NTD) (red spheres), bridging solenoid (blue spheres), core solenoid (purple spheres), and transmembrane domain (orange spheres) viewed from the side (left) and from the cytosol (right). Insets show the domain–domain interface between the NTD and the bridging solenoid at the ‘zipping’ point where DP4 (magenta) is located. In the right inset, the interaction between the NTD-A (cyan) and NTD-B of the adjacent protomer (green) also shows mutation clusters on both sides of this domain–domain interface.

Clusters of Mutation Hot Spots. Disease-causing ryanodine receptor 1 (RyR1) mutations (http://www.uniprot.org/uniprot/P21817) in the N-terminal domain (NTD) (red spheres), bridging solenoid (blue spheres), core solenoid (purple spheres), and transmembrane domain (orange spheres) viewed from the side (left) and from the cytosol (right). Insets show the domain–domain interface between the NTD and the bridging solenoid at the ‘zipping’ point where DP4 (magenta) is located. In the right inset, the interaction between the NTD-A (cyan) and NTD-B of the adjacent protomer (green) also shows mutation clusters on both sides of this domain–domain interface.


 
 
 

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